Hepatitis B Core Antibody (Anti-HBC) IgM, Serum
- Reporting Time:
- 6 Hrs
- Specimen Type:
- Home Collection:
- No special preparation required
Parameters Covered in the above test : 2
HBc IgM test is used to diagnose the disease status of Hepatitis B virus infection, whether it is acute or Chronic.
HBc IgM is a specific serological marker for recent or ongoing Hepatitis B infection. When suspecting acute Hepatitis B infection HBc IgM test along with HBsAg tests are necessary.
Hepatitis B virus is a DNA virus. In the acute phase of Hepatitis B infection, anti Hepatitis B core IgM antibodies (Anti-HBc IgM) appear shortly after the onset of symptoms. Anti-HBc IgM antibody can be detected in serum and is usually present for up to 6 months after acute HBV infection. The only serological marker of recent Hepatitis B infection is Anti-HBc which is detected after disappearance of hepatitis B surface antigen (HBsAg) and before the appearance of hepatitis B surface antibody (anti-HBs) which is called serological window period. Viral specific HBC IgM antibody has been detected in most acute viral infections and is a reliable marker of acute disease. Anti-HBc IgM levels increase rapidly in patients with acute infection. High levels of anti-HBc IgM have been detected in patients with acute hepatitis B viral infection. Hepatitis B surface antigen (HBsAg) will generally also be present as a serological marker of an acute infection, but there are reports of HBsAg being undetectable. In the convalescent phase, anti-HBc IgM will persist after the disappearance of HBsAg and decrease slowly over time. In the absence of information about any other hepatitis B virus (HBV) markers, it must be considered that an individual with detectable levels of anti-HBc IgM may be actively infected with HBV or that the infection might have resolved. Anti-HBc IgM may also be present in patients with chronic hepatitis B viral infection. The concentrations are generally lower than those associated with acute infections and may rise and fall with exacerbation of the disease. Differentiation of acute and chronic hepatitis B viral infection solely on the basis of viral markers, which are also frequently present, such as HBsAg, anti-HBs, HBeAg, anti-HBe, and anti-HBc, is difficult because most of these markers occur in both acute and chronic disease.
1. What are the different types of Hepatitis infection?
Hepatitis A virus, Hepatitis E virus, Hepatitis B surface Antigen, Hepatitis C Virus. These diseases caused by different types of viruses. Hepatitis A virus is transmitted through faeco-oral route by drinking contaminated water or Food. The disesase is acute not chronic. Hepatitis B and C viral infections begin as acute, but in some persons the virus remains in the body and become chronic.
2. What is the mode of Transmission of Hepatitis B virus?
a. During Birth spread from an infected mother to child.
b. Sexual transmission.
c. By Sharing needles, syringes, or other drug-injection equipment.
d. By direct contact with the blood or open wounds of an infected person.
e. Exposure to blood from needle sticks or other sharp instruments.
3. What are different types of Hepatitis markers to evaluate Hepatitis B disease condition?
a. HBs Ag: This is the first antigen appeared during Acute infection. It is also present in the chronic stage.
b. Hepatitis B core Antibody Total (Anti-HBC):
HBc antibody produced by the body against Hepatitis B virus called the ”core antigen.” A positive test means:A person is either currently infected with the Hepatitis B virus or was infected in the past.
c. Hepatitis B core IgM antibody(Anti-HBc IgM): Itis used to detect acute infection.
d. Hepatitis “B e’’ Antigen: High levels of HBe Ag present in the blood during acute Hepatitis B virus infection. This test is used to monitor the effectiveness of treatment.
e. Hepatitis “B e’’ Antibody:This is Antibody produced against Hepatitis “B e’’ Antigen.The positive test indicates chronic infection.
f. Hepatitis B viral Load: The test is used to prescence of Hepatiits B viral DNA in the blood.High levels of viral load is the indication of acute infection. This test is used to monitor the effectiveness of treatment.
4. What are the preventive measures used for Hepatitis B virus infection?
Vaccination with Hepatitis B is the best preventive measure to protect against Hepatitis B virus infection. After vaccination , antibodies are produced against virus and gives protection.