C4 Complement, Serum
- Reporting Time:
- 6 Hrs
- Specimen Type:
- Home Collection:
- No special preparation required
To determine deficiencies or abnormalities related to complement system proteins. To diagnose and monitor the treatment of autoimmune diseases and diseases related to immune complex.
When there are frequent microbial bacterial infections, inflammation and edema without any known underlying cause, symptoms suggesting an autoimmune disorder and to periodically monitor the course and treatment of a known acute or chronic condition that affects the complement system.
1. What are the components of innate immune system?
Phagocytic system (white blood cells, including neutrophils and monocytes/macrophages), Inflammatory mediators produced by basophils, mast cells and eosinophils, Natural killer (NK), B and T cells that are specialized and acute phase reactants and cytokines.
2. What are the functions of complement system?
Phagocytosis, inflammation and membrane attack are the primary functions of complement system.
3. What are the consequences of complement protein deficiencies?
Deficiencies of the complement system are associated with autoimmune disease and infections (Neisseria meningitidis). Complement system might play a role in many diseases associated with immune component like asthma, lupus erythematosus, glomerulonephritis, various forms of arthritis, multiple sclerosis, inflammatory bowel disease, atypical hemolytic uremic syndrome and rejection of transplanted organs.