Valproic Acid (Valproate), Serum

The valproic acid test helps to determine the valproic acid levels in blood and to maintain valproic acid levels at normal (therapeutic) level. The valproic acid test is required for dose adjustments and to ensure that the therapeutic levels of valproic acid are maintained. The valproic acid test is done when additional medications are given, to judge their effects on valproic acid levels. The valproic acid test is also done when there is recurrence of seizure, a migraine, or bipolar mood swings etc. In some cases, free valproic acid test is also done to monitor the levels of valproic acid levels in blood. Valproic acid in the blood is highly bound to proteins and only a small portion remains unbound (free), which is the pharmacologically active form. Normally there is a stable balance between bound and unbound valproic acid in the blood, hence measuring the total valproic acid is sufficient for monitoring the therapeutic levels of valproic acid. This balance is disturbed in certain conditions, where the percentage of free valproic acid increases and total valproic acid levels remain within the normal (therapeutic) range. In such situations the person experiences symptoms of toxicity.

1. How long must a person take valproic acid?

Valproic acid is usually taken every day (sometimes several times a day) for an entire life time. However if seizures are caused by a temporary condition, then valproic acid is needed only for a short period of time.

2. What are the forms of valproic acid?

Valproic acid is available as tablets, slow release tablet, liquid, or powder sprinkled on food.

3. What are the side effects of valproic acid?

Allergic reactions, severe skin reactions, confusion, tiredness, nausea & vomiting, bleeding from nose, mouth, or gums, red pinpoint spots under the skin, severe drowsiness, seizures, etc.